BIOEQUIVALENCE EVALUATION OF ORALLY DISINTEGRATING STRIPS OF RIZATRIPTAN IN MALE VOLUNTEERS UNDER FASTING CONDITIONS

(rizatriptan Benzoate) Orally Disintegrating Tablets

Its empirical formula is C15H19N5•C7H6O2, representing a molecular weight of the free base of 269.4. Rizatriptan benzoate is a white to off-white, crystalline solid that is soluble in water at about 42 mg per mL (expressed as free base) at 25°C. MAXALT Tablets and MAXALT-MLT* Orally Disintegrating Tablets are available for oral administration in strengths of 5 and 10 mg (corresponding to 7.265 ...

formulation and physicochemical evaluation of rizatriptan orally disintegrating tablet

Bioequivalence study of two formulations of flupirtine maleate capsules in healthy male Chinese volunteers under fasting and fed conditions

Aim This study developed a high-performance liquid chromatography-tandem mass spectrometry method to simultaneously determine the concentrations of flupirtine and its major active metabolite D-13223 in human plasma in order to assess the bioequivalence (BE) of two flupirtine maleate capsules among healthy male Chinese volunteers under fasting and fed conditions. Materials and methods There we...

Formulation and in vitro evaluation of orally disintegrating film of alprazolam

Background: Over the past years, orally disintegrating films (ODFs) have been a suitable alternative to conventional oral dosage forms such as tablets and capsules, especially for patients with dysphagia. ODF is relatively a new dosage form which is prepared using hydrophilic polymers, which rapidly dissolve on tongue or buccal cavity and has other advantages of rapid onset of action and improv...

Two-way Crossover Bioequivalence Study of Rosuvastatin Tablets 5 Mg in Healthy, Adult, Asian-indian Male Volunteers under Fasting Condition

Objective: To compare the bioavailability and characterize the pharmacokinetic profile of the test and reference formulations of rosuvastatin tablets 5 mg in healthy, adult, Asian-Indian male volunteers under fasting condition. Methods: An open label, randomized, two-treatment, two-period, two-sequence, single dose, two-way crossover study was conducted in forty healthy adult volunteers. All th...